Sean Michael O'Bryan (born September 10, 1963) is an American film and television actor from Louisville, Kentucky. He attended and graduated from St. Xavier High School.

This biography of a living person does not include any references or sources. (December 2023)

He co-starred with William Ragsdale on the series Brother's Keeper. Early television work includes guest roles on such television series as Married... with Children, MacGyver, Northern Exposure, Cold Case, Diagnosis: Murder, Quantum Leap, Murder, She Wrote, Chicago Hope, Roswell (season 3 episode 9), Roseanne (season 8 episode 19), Six Feet Under, Criminal Minds, The King of Queens and Dexter. More recent television credits include CSI, Bones, Melissa & Joey, Hot In Cleveland, The Mentalist, Leverage. He appears in the recurring role of Ron Donahue on The Middle.

His film credits include Chaplin, Crimson Tide, Phenomenon, Exit to Eden, Out to Sea, Big Fat Liar, Detective, Deck the Halls, I'll Be Home for Christmas, Yes Man, Vantage Point and both Princess Diaries films. His more recent films include Playing for Keeps, Olympus Has Fallen, London Has Fallen and Mother's Day.

O'Bryan moved to Los Angeles in the early 1990s, where he now resides with his wife, actress Samantha Follows (sister of Canadian-American actress Megan Follows). They wed in 1995 and have two daughters.