The Santa Ana Handicap is a Thoroughbred horse race run at annually Santa Anita Park in Arcadia, California during the third week of March. The race is open to fillies and mares, age four and up, willing to race one and one-quarter miles on the turf.

A Grade III event, it currently offers a purse of $200,000.

In 1973 the race was run in two divisions. In 1981, 1982, 1983 and 1986, it was raced on dirt.

Speed record: (on turf)

• 1:59.24 – Elysea's World (2019)

Most wins:

• No horse has won this race more than once.

Most wins by an owner:

• 3 – Juddmonte Farms (1995, 2000, 2008)

Most wins by a jockey:

• 4 – Bill Shoemaker (1972, 1974, 1984, 1987)
• 4 – Kent Desormeaux (1991, 1994, 1998, 1999)

Most wins by a trainer:

• 8 – Robert J. Frankel (1992, 1994, 1995, 1999, 2000, 2005, 2007, 2008)

• The 2008 Santa Ana Handicap at the NTRA