Samuel Isaac Hopkins (December 12, 1843 – January 15, 1914) was a U.S. Representative from Virginia.

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Samuel I. Hopkins
Member of the U.S. House of Representatives from Virginia's 6th district
In office March 4, 1887 – March 3, 1889
Preceded by	John W. Daniel
Succeeded by	Paul C. Edmunds
Personal details
Born	(1843-12-12)December 12, 1843 Owensville, Maryland
Died	January 15, 1914(1914-01-15) (aged 70) Lynchburg, Virginia
Resting place	Spring Hill Cemetery[1] Lynchburg, Virginia
Political party	Labor
Profession	Politician, Merchant
Military service
Allegiance	Confederate States
Branch/service	Confederate States Army
Rank	Private
Unit	2nd Maryland Infantry
Battles/wars	American Civil War Battle of Gettysburg

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Born near Owensville, Maryland, Hopkins moved to Anne Arundel County with his parents, who settled near Annapolis. He attended the common schools and graduated from Owensville Academy. Hopkins enlisted in Company A, Second Regiment, Maryland Confederate Infantry, during the Civil War and served until he was severely wounded at the Battle of Gettysburg. After the war, he settled in Lynchburg, Virginia, and engaged in mercantile pursuits.

Hopkins was elected as a candidate of the Labor Party to the Fiftieth Congress (March 4, 1887 – March 3, 1889). He declined to be a candidate for renomination in 1888. Hopkins resumed mercantile pursuits in Lynchburg, Virginia, and died there on January 15, 1914. He was interred in Spring Hill Cemetery in Lynchburg.

1886; Hopkins was elected to the U.S. House of Representatives with 51.55% of the vote, defeating Democrat Samuel Griffin.