SLC50A1

Sugar transporter SWEET1

Sugar transporter SWEET1

Protein-coding gene in the species Homo sapiens

Sugar transporter SWEET1, also known as RAG1-activating protein 1 and stromal cell protein (SCP), is a membrane protein that in humans is encoded by the SLC50A1 gene.[5] SWEET1 is the sole transporter from the SLC50 (SWEET) gene family present in the genomes of most animal species, with the exception of the nematode Caenorhabditis elegans, which has seven.[6]

Quick Facts SLC50A1, Identifiers ...

SWEET1 is a broadly-expressed glucose transporter.[6] As the SWEET family has been identified relatively recently, the full range of its functions in animals is not yet clear.[7] However, the bovine SLC50A1 homologue is associated with lactose concentration in milk,[8] and the CiRGA homologue in the sea squirt Ciona intestinalis is essential for tissue differentiation during embryogenesis, especially the development of the notochord.[9] SWEET genes are common in plant genomes, with around twenty paralogues [6] functioning as both sucrose and hexose transporters, and are also associated with pathogen susceptibility.[6][10]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000169241 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000027953 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: Solute carrier family 50 (sugar efflux transporter), member 1".
  6. [6]
    Feng L, Frommer WB (2015). "Structure and function of SemiSWEET and SWEET sugar transporters". Trends in Biochemical Sciences. 40 (8): 480–486. doi:10.1016/j.tibs.2015.05.005. PMID 26071195.
  7. [7]
    Deng D, Yan N (2016). "GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters". Protein Science. 25 (3): 546–558. doi:10.1002/pro.2858. PMC 4815417. PMID 26650681.
  8. [8]
    Lopdell TJ, Tiplady K, Struchalin M, Johnson TJ, Keehan M, Sherlock R, Couldrey C, Davis SR, Snell RG, Spelman RJ, Littlejohn MD (2017). "DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content". BMC Genomics. 18 (1): 968. doi:10.1186/s12864-017-4320-3. PMC 5731188. PMID 29246110.
  9. [9]
    Hamada M, Wada S, Kobayashi K, Satoh N (2005). "Ci-Rga, a gene encoding an MtN3/saliva family transmembrane protein, is essential for tissue differentiation during embryogenesis of the ascidian Ciona intestinalis". Differentiation. 73 (7): 364–376. doi:10.1111/j.1432-0436.2005.00037.x. PMID 16219040.
  10. [10]
    Wright EM (2013). "Glucose transport families SLC5 and SLC50". Molecular Aspects of Medicine. 34 (2–3): 183–196. doi:10.1016/j.mam.2012.11.002. PMID 23506865.

Further reading


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