SLC30A1
Zinc transporter 1
Protein found in humans
Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.[5][6]
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SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[7]
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- Zhang LH, Wang X, Stoltenberg M, et al. (2008). "Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain". Brain Res. Bull. 77 (1): 55–60. doi:10.1016/j.brainresbull.2008.03.014. PMID 18639746. S2CID 33951242.
- Lovell MA, Smith JL, Xiong S, Markesbery WR (2005). "Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease". Neurotoxicity Research. 7 (4): 265–71. doi:10.1007/BF03033884. PMID 16179263. S2CID 11433.
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- Iguchi K, Otsuka T, Usui S, et al. (2004). "Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells". J. Androl. 25 (1): 154–61. doi:10.1002/j.1939-4640.2004.tb02771.x. PMID 14662799.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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- Overbeck S, Uciechowski P, Ackland ML, et al. (2008). "Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9". J. Leukoc. Biol. 83 (2): 368–80. doi:10.1189/jlb.0307148. PMID 17971500. S2CID 21801798.
- Hosgood HD, Menashe I, He X, et al. (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respiratory Medicine. 103 (12): 1866–1870. doi:10.1016/j.rmed.2009.06.016. PMC 2783799. PMID 19625176.
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- Etzion Y, Ganiel A, Beharier O, et al. (2008). "Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study". J. Cardiovasc. Electrophysiol. 19 (2): 157–64. doi:10.1111/j.1540-8167.2007.01008.x. PMID 17971132. S2CID 8430908.
- Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
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