SLC25A21

Mitochondrial 2-oxodicarboxylate carrier

Mitochondrial 2-oxodicarboxylate carrier

Protein-coding gene in the species Homo sapiens

Mitochondrial 2-oxodicarboxylate carrier also known as solute carrier family 25 member 21 (SLC25A21) is a protein that in humans is encoded by the SLC25A21 gene.[5]

Quick Facts SLC25A21, Identifiers ...

It is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[5]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000183032 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000035472 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21". Retrieved 2011-12-04.

Further reading


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