S64 may refer to:

• Blériot-SPAD S.64, a French biplane trainer
• Savoia-Marchetti S.64, an Italian endurance aircraft
• Sikorsky S-64 Skycrane, later the Erickson S-64 Aircrane, an American helicopter
• Stanford Airport, in Judith Basin County, Montana, United States

• S64 (Long Island bus)
• Dharug language
• S64: If swallowed, rinse mouth with water (only if the person is conscious), a safety phrase
• Spanish submarine Narval (S 64)
• S64, a postcode district for Mexborough, England

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