The Roland U-110 is a ROMpler synthesizer module that was produced by Roland Corporation in 1988.

The predecessor of the more successful U-20 keyboard and U-220 module, the U-110 was Roland's first dedicated sample playback synth. It used ROM to store sounds rather than loading them from disks into RAM, hence it was not a true sampler as it could not sample sounds.

The U-110 contained a base 2MB of sounds stored in ROM. It could be expanded with up to four Roland SN-U110 sound library cards, unlike the more popular Roland U-220 that could only accommodate two. It had six individual outputs, allowing for each instrument channel to be recorded separately, and two mix outputs to output all channels as a stereo pair.