RNA_Velocity
RNA velocity
Brief introduction of RNA Velocity and softwares.
RNA velocity is based on bridging measurements to a underlying mechanism, mRNA splicing, with two modes indicating the current and future state.[1] It is a method used to predict the future gene expression of a cell based on the measurement of both spliced and unspliced transcripts of mRNA.[2]
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RNA velocity could be used to infer the direction of gene expression changes in single-cell RNA sequencing (scRNA-seq) data. It provides insights into the future state of individual cells by using the abundance of unspliced to spliced RNA transcripts. This ratio can indicate the transcriptional dynamics and potential fate of a cell, such as whether it is transitioning from one cell type to another or undergoing differentiation.[3]