RIF1

Telomere-associated protein RIF1

Telomere-associated protein RIF1

Protein

Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.[5][6][7]

Quick Facts RIF1, Identifiers ...

RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast.[8] In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.[9]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000080345 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000036202 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T (September 2004). "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint". Genes & Development. 18 (17): 2108–19. doi:10.1101/gad.1216004. PMC 515289. PMID 15342490.
  6. [6]
    Adams IR, McLaren A (April 2004). "Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells". Developmental Dynamics. 229 (4): 733–44. doi:10.1002/dvdy.10471. PMID 15042697. S2CID 22138565.
  7. [7]
    "Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast)".
  8. [8]
    Ribeyre C, Shore D (2012). "Anticheckpoint pathways at telomeres in yeast". Nature Structural & Molecular Biology. 19 (3): 307–13. doi:10.1038/nsmb.2225. PMID 22343724. S2CID 10636976.
  9. [9]
    Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA (2016-01-01). "Serial interactome capture of the human cell nucleus". Nature Communications. 7: 11212. Bibcode:2016NatCo...711212C. doi:10.1038/ncomms11212. PMC 4822031. PMID 27040163.

Further reading

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