A protein mimetic is a molecule such as a peptide, a modified peptide or any other molecule that biologically mimics the action or activity of some other protein. Protein mimetics are commonly used in drug design and discovery.

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There are a number of different distinct classes of protein mimetics.

• Antibody mimetic - Molecules that mimic antigen binding activity of antibodies
• Peptidomimetic - Small protein-like chains designed to mimic larger peptide.
• Phosphomimetics - An amino acid substitution or modification which mimic the effect of protein phosphorylation.

• Homology (biology)