Procollagen_peptidase

Procollagen peptidase

Procollagen peptidase

Class of enzymes

Procollagen peptidase (EC 3.4.24.14, procollagen N-terminal peptidase, procollagen aminopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, procollagen aminoterminal protease, procollagen N-terminal proteinase, type I/II procollagen N-proteinase, type III procollagen) is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome.[1]

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The enzyme is present in the skin of rats and humans.[2]

References

  1. [1]
    "Procollagen peptidase". 7 October 2019.
  2. [2]
    Lapière CM, Lenaers A, Kohn LD (December 1971). "Procollagen peptidase: an enzyme excising the coordination peptides of procollagen". Proceedings of the National Academy of Sciences of the United States of America. 68 (12): 3054–8. Bibcode:1971PNAS...68.3054L. doi:10.1073/pnas.68.12.3054. PMC 389589. PMID 5289249.


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