Phosphinothricin_acetyltransferase

Phosphinothricin acetyltransferase

Phosphinothricin acetyltransferase

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Phosphinothricin acetyltransferase (EC 2.3.1.183, PAT, PPT acetyltransferase, Pt-N-acetyltransferase, ac-Pt) is an enzyme with systematic name acetyl-CoA:phosphinothricin N-acetyltransferase.[1][2] This enzyme catalyses the following chemical reaction

acetyl-CoA + phosphinothricin CoA + N-acetylphosphinothricin
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The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2.

Reaction.

References

  1. [1]
    Botterman J, Gosselé V, Thoen C, Lauwereys M (June 1991). "Characterization of phosphinothricin acetyltransferase and C-terminal enzymatically active fusion proteins". Gene. 102 (1): 33–7. doi:10.1016/0378-1119(91)90534-i. PMID 1864506.
  2. [2]
    Droge-Laser W, Siemeling U, Puhler A, Broer I (May 1994). "The Metabolites of the Herbicide L-Phosphinothricin (Glufosinate) (Identification, Stability, and Mobility in Transgenic, Herbicide-Resistant, and Untransformed Plants)". Plant Physiology. 105 (1): 159–166. doi:10.1104/pp.105.1.159. PMC 159341. PMID 12232195.
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