Phosalacine

Phosalacine

Phosalacine

Chemical compound

Phosalacine is a natural antimicrobial and herbicidal compound that has been isolated from the Actinobacteria Kitasatosporia phosalacinea.[1]

Quick Facts Names, Identifiers ...

It is a tripeptide consisting of the amino acids glufosinate (phosphinothricin), alanine, and leucine.[2] It is similar in structure to bialaphos, differing by replacement of the terminal alanine with leucine.

Phosalacine has antimicrobial activity against Gram-positive and Gram-negative bacteria and some fungi.[1] It also shows herbicidal activity against alfalfa.[1] It is believed that the herbicidal activity is due to the slow release of glufosinate,[3] which is a commercially-used broad spectrum herbicide.

References

  1. [1]
    Omura, Satoshi; Murata, Masatsune; Hanaki, Hideaki; Hinotozawa, Kiyoizumi; Oiwa, Ruiko; Tanaka, Haruo (1984). "Phosalacine, a new herbicidal antibiotic containing phosphinothricin. Fermentation, isolation, biological activity and mechanism of action". The Journal of Antibiotics. 37 (8): 829–835. doi:10.7164/antibiotics.37.829. PMID 6480502.
  2. [2]
    Omura, Satoshi; Hinotozawa, Kiyoizumi; Imamura, Nobutaka; Murata, Masatsune (1984). "The structure of phosalacine, a new herbicidal antibiotic containing phosphinothricin". The Journal of Antibiotics. 37 (8): 939–940. doi:10.7164/antibiotics.37.939. PMID 6480509. S2CID 9186238.
  3. [3]
    Hoagland, Robert E. (1988). "Naturally Occurring Carbon—Phosphorus Compounds as Herbicides". Biologically Active Natural Products. ACS Symposium Series. Vol. 380. pp. 182–210. doi:10.1021/bk-1988-0380.ch013. ISBN 9780841215566.
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