In enzymology, a phloroglucinol reductase (EC 1.3.1.57) is an enzyme that catalyzes the chemical reaction

dihydrophloroglucinol + NADP⁺ ${\displaystyle \rightleftharpoons }$ phloroglucinol + NADPH + H⁺

Thus, the two substrates of this enzyme are dihydrophloroglucinol and NADP⁺, whereas its 3 products are phloroglucinol, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dihydrophloroglucinol:NADP+ oxidoreductase. This enzyme participates in benzoate degradation via coa ligation.