Phenylalanine_2-monooxygenase

Phenylalanine 2-monooxygenase

Phenylalanine 2-monooxygenase

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In enzymology, a phenylalanine 2-monooxygenase (EC 1.13.12.9) is an enzyme that catalyzes the chemical reaction

L-phenylalanine + O2 2-phenylacetamide + CO2 + H2O
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Thus, the two substrates of this enzyme are L-phenylalanine and O2, whereas its 3 products are 2-phenylacetamide, CO2, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating). Other names in common use include L-phenylalanine oxidase (deaminating and decarboxylating), and phenylalanine (deaminating, decarboxylating)oxidase. This enzyme participates in phenylalanine metabolism.

References

    • Koyama H (October 1982). "Purification and characterization of a novel L-phenylalanine oxidase (Deaminating and decarboxylating) from Pseudomonas sp. P-501". J. Biochem. 92 (4). Tokyo: 1235–40. PMID 7174643.
    • Koyama H (August 1984). "Oxidation and oxygenation of L-amino acids catalyzed by a L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501". J. Biochem. 96 (2). Tokyo: 421–7. PMID 6501250.
    • Koyama H (1984). "A simple and rapid enzymatic determination of L-phenylalanine with a novel L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501". Clin. Chim. Acta. 136 (2–3): 131–6. doi:10.1016/0009-8981(84)90284-5. PMID 6692570.
    • Koyama H, Suzuki H (October 1986). "Spectral and kinetic studies on Pseudomonas L-phenylalanine oxidase (deaminating and decarboxylating)". J. Biochem. 100 (4). Tokyo: 859–66. PMID 3818566.


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