Oxoglutarate_dehydrogenase_(NADP+)

Oxoglutarate dehydrogenase (NADP+)

Oxoglutarate dehydrogenase (NADP+)

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In enzymology, an oxoglutarate dehydrogenase (NADP+) (EC 1.2.1.52) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate + CoA + NADP+ succinyl-CoA + CO2 + NADPH
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The 3 substrates of this enzyme are 2-oxoglutarate, CoA, and NADP+, whereas its 3 products are succinyl-CoA, CO2, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating). This enzyme is also called oxoglutarate dehydrogenase (NADP+).

References

    • Inui H, Miyatake K, Nakano Y, Kitaoka S (September 1984). "Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis". J. Biochem. 96 (3). Tokyo: 931–4. doi:10.1093/oxfordjournals.jbchem.a134913. PMID 6438078.


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