Orion 2 or Orion-2 may refer to:

• Orion 2, a space telescope flown in 1973 aboard the Soyuz 13 spacecraft
• Orión-2, a sounding rocket from Argentina, used from 1966 to 1971
• Orion 2, a communications satellite launched in 1999, later renamed Telstar 12
• Orion capsule space mission 2, formerly the Exploration Mission 1, Artemis 1
• Mission Orion 2 of the cancelled Constellation program, see List of Constellation missions

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• 2 Orionis, a star in the Constellation Orion

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