In enzymology, an octanol dehydrogenase (EC 1.1.1.73) is an enzyme that catalyzes the chemical reaction

1-octanol + NAD⁺ ${\displaystyle \rightleftharpoons }$ 1-octanal + NADH + H⁺

Thus, the two substrates of this enzyme are 1-octanol and NAD⁺, whereas its 3 products are 1-octanal, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is octanol:NAD⁺ oxidoreductase. This enzyme is also called 1-octanol dehydrogenase.