Nitric_oxide_reductase_(NAD(P),_nitrous_oxide-forming)

Nitric oxide reductase (NAD(P), nitrous oxide-forming)

Nitric oxide reductase (NAD(P), nitrous oxide-forming)

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Nitric oxide reductase (NAD(P), nitrous oxide-forming) (EC 1.7.1.14, fungal nitric oxide reductase, cytochrome P450nor, NOR (ambiguous)) is an enzyme with systematic name nitrous oxide:NAD(P) oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

N2O + NAD(P)+ + H
2O 2 NO + NAD(P)H + H+
Quick Facts Identifiers, EC no. ...

This enzyme is heme-thiolate protein (P450).

References

  1. [1]
    Shoun H, Tanimoto T (June 1991). "Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 in the respiratory nitrite reduction". The Journal of Biological Chemistry. 266 (17): 11078–82. PMID 2040619.
  2. [2]
    Shiro Y, Fujii M, Iizuka T, Adachi S, Tsukamoto K, Nakahara K, Shoun H (January 1995). "Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide. Implication for its nitric oxide reduction mechanism". The Journal of Biological Chemistry. 270 (4): 1617–23. PMID 7829493.
  3. [3]
    Zhang L, Kudo T, Takaya N, Shoun H (September 2002). "The B' helix determines cytochrome P450nor specificity for the electron donors NADH and NADPH". The Journal of Biological Chemistry. 277 (37): 33842–7. doi:10.1074/jbc.M203923200. PMID 12105197.
  4. [4]
    Oshima R, Fushinobu S, Su F, Zhang L, Takaya N, Shoun H (September 2004). "Structural evidence for direct hydride transfer from NADH to cytochrome P450nor". Journal of Molecular Biology. 342 (1): 207–17. doi:10.1016/j.jmb.2004.07.009. PMID 15313618.
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