Nikhom Kham Soi (Thai: นิคมคำสร้อย, pronounced [ní(ʔ).kʰōm kʰām sɔ̂j]) is a district (amphoe) of Mukdahan province, northeastern Thailand.

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Nikhom Kham Soi นิคมคำสร้อย
District
Thailand Rte 212, Chayangkun Rd, Na Kok village
District location in Mukdahan province
Coordinates: 16°22′18″N 104°33′2″E
Country	Thailand
Province	Mukdahan
Seat	Nikhom Kham Soi
Area
• Total	377.2 km2 (145.6 sq mi)
Population  (2005)
• Total	42,225
• Density	111.9/km2 (290/sq mi)
Time zone	UTC+7 (ICT)
Postal code	49130
Geocode	4902

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Neighboring districts are (from the west clockwise) Nong Sung, Mueang Mukdahan and Don Tan of Mukdahan Province, and Loeng Nok Tha of Yasothon province.

The minor district (king amphoe) was established on 2 June 1975, when the five tambons Nikhom Kham Soi, Na Kok, Na Udom, Nong Waeng, and Kok Daeng were split off from Mukdahan district.^[1] It was upgraded to a full district on 25 March 1979.^[2] When Mukdahan Province was created in 1982, Nikhom Kham Soi was one of the districts forming the new province.

The district is divided into seven sub-districts (tambons), which are further subdivided into 79 villages (mubans). Nikhom Kham Soi is a township (thesaban tambon) which covers parts of the tambon Nikhom Kham Soi, Na Kok, and Chok Chai. There are a further seven tambon administrative organization (TAO).