Neoptolemus may refer to the following people:

• Neoptolemus, son of Achilles and Deidamia in Greek mythology
• Neoptolemus (general) (died 321), general of Alexander the Great
• Neoptolemus I of Epirus, king of Epirus, son of Alcetas I, father of Alexander I of Epirus and Olympias, grandfather of Alexander the Great
• Neoptolemus II of Epirus, king of Epirus, nephew of Alexander the Great
• Neoptolemus (Pontic army officer), general of King Mithradates Eupator

This disambiguation page lists articles about people with the same name.
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