National Highway 2 (NR2) is a south–north flowing highway of central-western Burma.

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The highway begins at Satthwadaw, to the north of Yangon at 17°2′30″N 96°7′56″E where it is fed by the National Highway 1 and then branches off to the northwest. At Myingyan it joins the National Road 18. At this point the road forks to the east and eventually rejoins National Highway 1 near the village of Gyobinchan in Myittha Township at 21°22′59″N 96°10′32″E. The highway mostly follows the course of the Ayeyarwady River on its eastern bank.

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