Season 1

While attempting to represent Betsy and Craig Kettleman, a couple accused of embezzling $1.6 million, Jimmy McGill has a run-in with Tuco, who has Nacho and other associates drag Jimmy to the desert to kill him. Nacho believes Jimmy's plea that he is a lawyer and convinces Tuco that killing an attorney would result in police scrutiny of the Salamanca family's drug business, so Tuco lets Jimmy go. Nacho later approaches Jimmy about stealing the money from the Kettlemans, but Jimmy refuses.^[8] Jimmy warns the Kettlemans, who disappear from their home. Nacho is the prime suspect and is arrested. He coerces Jimmy into helping clear his name and Jimmy locates the Kettlemans, which leads to Nacho's release.^[9][10]

Nacho engages in a side deal with "Pryce", who wants to sell pills stolen from the pharmaceutical company where he works. Pryce brings Mike Ehrmantraut as a bodyguard. When Nacho's payment is $20 short, Mike insists he pay the full amount. As Pryce and Mike leave, Mike explains that he knew Nacho was conducting the transaction without the Salamancas' knowledge and so had an incentive to make sure the deal went smoothly.^[11]

Season 2

Pryce uses his drug money to buy a flashy Hummer. Mike refuses to participate in the next deal, so Pryce goes alone. Nacho takes the opportunity to learn Pryce's real name — Daniel Wormald — and address. He later breaks into Daniel's house and steals the money back, along with a valuable collection of baseball cards. Daniel reports the collection's theft to the police, who discover an empty hiding place.^[12] Mike realizes his involvement will be uncovered if police continue to investigate, so he convinces Nacho to give Daniel the cards and $10,000 in exchange for the Hummer.^[13]

Nacho is impressed by Mike's candor and coolness under pressure. As Tuco becomes increasingly volatile, potentially exposing the Salamanca organization, and the likelihood of his learning about Nacho's secret deals increases, Nacho decides to eliminate Tuco and tries to hire Mike to kill him, but Mike instead arranges for Tuco to attack him in view of police, leading to Tuco's arrest and conviction.^[14] Hector Salamanca has Nacho take Tuco's place in the organization. Mike becomes fearful that Hector may discover his role in removing Tuco from the family's operations. He attempts to draw police attention to the Salamanca operation by hijacking one of the trucks used to smuggle drugs over the Mexican border, leaving the driver tied up and gagged at the side of the road and stealing the US$250,000 hidden in one of the tires. Nacho tells Mike that Hector covered up the hijacking by killing the Good Samaritan who stopped to aid the driver.^[15]

Season 3

Mike's actions lead to Hector looking for other routes to smuggle drugs, and he considers using Nacho's father Manuel's upholstery shop. Nacho objects but fails to change Hector's mind. In pleading with his father, Nacho reveals his involvement in the Salamanca organization. Manuel accepts Hector's initial payment after Nacho convinces him that doing so is for his own safety. Nacho realizes Hector suffers from angina and decides to try to kill him by replacing his nitroglycerin with ibuprofen in the hopes of inducing a fatal heart attack.^[16] Mike advises Nacho that if Hector dies, Nacho should immediately take the ibuprofen capsules from Hector and replace them with the real ones so that the cause of Hector's death will not be obvious.^[17]

Nacho succeeds in making the switch, but Hector does not die,^[18] so Nacho plans to shoot him. Before he can act, Nacho is notified to attend a meeting with Gus Fring, Juan Bolsa, and Hector. Juan informs Hector that cartel leader Don Eladio has decreed that the cartel will make the transport of Hector's drugs via Gus's trucks a permanent arrangement. An outraged Hector has a stroke and falls to the ground unconscious. Gus performs first aid while awaiting an ambulance, and succeeds in saving Hector's life, though he remains comatose. Nacho takes the ibuprofen capsules from Hector and replaces them with real medication. Gus looks at Nacho suspiciously.^[19]

Season 4

Juan tells Nacho that he and Arturo will run the Salamanca family while Hector is hospitalized.^[20] Gus pays for Hector's specialized care, and while reviewing Hector's medical records, realizes there is no nitroglycerin in his system, meaning Nacho tried to kill him. When Nacho and Arturo arrive at Gus' chicken farm to pick up their next cocaine shipment, Gus suddenly ambushes Arturo and suffocates him with a plastic bag. Gus reveals that he is aware of Nacho's attempt to kill Hector, but has not told the Salamancas, so Nacho is now under his control.^[21] Nacho, Victor, and Tyrus fake an ambush site on a remote road, which includes riddling Nacho's car with bullets, shooting Arturo's body, and wounding Nacho. Nacho succeeds in calling Leonel and Marco Salamanca (the Cousins) for help. They burn the car and take him to veterinarian Caldera, who succeeds in saving Nacho's life.^[22]

Victor sells the drugs taken from Nacho to the Espinosas, a rival gang. Nacho falsely identifies the Espinosas to Leonel and Marco as the ones who attacked him. They attack the Espinosa compound, kill everyone inside, and recover the "stolen" drugs. Nacho sees that by wiping out the Espinosas, Gus has secured more drug territory for himself, but does not yet see the full scope of Gus' plan. Nacho goes to his father's house to recover, and Manuel takes him in despite being unhappy about Nacho's ties to the Salamancas.^[23] After recovering, Nacho takes on a more prominent role in the Salamanca organization but also keeps a safe with cash and fake Canadian IDs for himself and his father. Nacho is surprised when Lalo Salamanca arrives to aid in running the business, and takes a stronger interest in the day-to-day details than Hector did.^[24]

Season 5

Gus threatens harm to Manuel to coerce Nacho into providing inside information on the Salamancas. Nacho tries to convince Manuel to move away, but Manuel refuses to leave. When one of the Salamanca drug houses is discovered by police and Domingo Molina is arrested, Nacho sneaks over rooftops to recover the drug stash before police enter, which impresses Lalo, who begins to take Nacho into his confidence.^[25] Nacho then brings Jimmy to Lalo so they can arrange to have Domingo released before he talks to police. Jimmy secures Domingo's release and assures his protection by making him a confidential informant for DEA agent Hank Schrader and having him reveal the location of Gus's dead drops. Lalo is pleased by their work, though Nacho warns Jimmy that once he begins working for drug dealers like the Salamancas, there is no turning back.^[26]

Nacho reports Lalo's plan for Gus's dead drops to Gus, who unhappily accepts the loss of nearly $1 million to keep secret Nacho's identity as a mole within the Salamanca organization.^[27] Unaware that Nacho knows Mike, Gus directs Nacho to report to him. Nacho tries to warn Mike about Gus's ruthlessness, but Mike reminds Nacho that he warned Nacho about the risk he was taking when he tried to kill Hector.^{[lower-alpha 1]} With Nacho's assistance, Mike poses as a private detective to feed the police information that ties Lalo to the murder of Fred Whalen, a money wire store clerk.^{[lower-alpha 2]} Lalo is arrested and held without bail,^[28] but he contacts Nacho and orders him to continue harassing Gus by destroying one of Gus's restaurants, which Nacho reports to Mike. Mike alerts Gus, who works with Nacho to destroy the restaurant, again keeping secret Nacho's role as Gus's mole.^[29]

Mike tells Gus that Nacho wants to end his role as a mole, but Gus refuses to give up a valuable asset. After obtaining bail, Lalo plans to return to Mexico, and Nacho drives him there.^[30] Nacho and Lalo arrive at Lalo's fortified hacienda in Chihuahua, which Mike reports to Gus. Gus says he has sent gunmen to kill Lalo and that Nacho may be able to help. Lalo introduces Nacho to his family and friends, and Nacho receives a call instructing him to leave Lalo's back gate open at 3 am. Lalo takes him to meet Eladio, who blesses Lalo and Nacho's plan for Nacho to run the Salamanca drug business in Lalo's absence. Lalo is awake at 3 am, so Nacho sets a kitchen fire as a distraction. When Lalo goes to investigate, Nacho opens the back gate and flees, while the gunmen kill Lalo's guards and most of his family. After Lalo kills all but one gunman and forces him to call the middleman who arranged the killing to report that Lalo is dead, he looks around and realizes that Nacho is missing.^[31]

Season 6

Nacho flees Lalo's compound and takes refuge at a motel arranged for by Gus. He calls Tyrus, who tells him to hide until it is safe to move. Nacho then attempts to reach Mike, who declines to take the call. Juan informs Gus that the cartel has placed a bounty on Nacho.^[32] Gus's men break into Nacho's safe, and Mike removes the cash and Nacho and Manuel's fake Canadian IDs. Victor delivers a duplicate safe, into which Mike places the cash, Nacho's fake ID, and an envelope. Juan finds the envelope, which contains the motel's phone number and details of an offshore bank account. Nacho realizes he is being surveilled, meaning Gus has betrayed him to the cartel. The Cousins search the motel but Nacho escapes. Mike has a standoff with Gus and Tyrus because Mike wants to lead a team to find Nacho but Gus wants to force Nacho to reveal himself by taking Manuel hostage.^[33]

Nacho places a farewell call to Manuel, then surrenders to Gus in exchange for assurances that Manuel will not be harmed. Gus, Tyrus, and Victor hand Nacho over to Juan, Hector, and the Cousins as Mike watches and trains his rifle on them. Nacho falsely claims Gus had no involvement in the attack on Lalo and reveals that he tried to kill Hector by switching his nitroglycerin for ibuprofen,^{[lower-alpha 3]} but that Gus saved him.^{[lower-alpha 4]} Rather than pretend to flee as planned so that Victor can kill him quickly, Nacho uses a piece of broken glass to free himself from his zip tie, seize Juan's gun, and kill himself. The Cousins then assist Hector to fire bullets into Nacho's lifeless body.^[34]

Lalo later confronts Jimmy and Kim Wexler in their apartment, ties Jimmy up, and asks if he had any involvement with the attack on his house since he knows Nacho. Jimmy denies any involvement and blames Nacho completely before Lalo gags him and promises to return later to continue the interrogation, but is killed by Gus before he can return.^[35] Afterwards, Mike informs Manuel of Nacho's fate.^[36]

Season 2

Though Nacho never appears in Breaking Bad, Saul mentions him when Walter White and Jesse Pinkman kidnap and hold Saul at gunpoint to coerce him into representing Badger, who has been arrested for selling drugs. Believing Walt and Jesse were sent by Lalo, he says in a panic, "It wasn't me, it was Ignacio! He's the one!" but is relieved when Walt and Jesse's confusion confirms they have no connection to Lalo.^{[lower-alpha 5][37]}