N-methyl-L-amino-acid_oxidase

N-methyl-L-amino-acid oxidase

N-methyl-L-amino-acid oxidase

Class of enzymes

In enzymology, a N-methyl-L-amino-acid oxidase (EC 1.5.3.2) is an enzyme that catalyzes the chemical reaction

an N-methyl-L-amino acid + H2O + O2 an L-amino acid + formaldehyde + H2O2
Quick Facts Identifiers, EC no. ...

The 3 substrates of this enzyme are N-methyl-L-amino acid, H2O, and O2, whereas its 3 products are L-amino acid, formaldehyde, and H2O2.

It has 2 cofactors: FAD, and Flavoprotein.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating). Other names in common use include N-methylamino acid oxidase, and demethylase.

References

    Further reading

    • Moritani M (1952). "Demethylase. IV. Kinetics and reaction mechanism". Hukuoka Acta Med. 43: 651–658.
    • Moritani M (1952). "Demethylase. V. Specificity and its relation to amino acid oxidase". Hukuoka Acta Med. 43: 731–735.
    • Moritani M, Tung TC, Fujii S, Mito H, Izumiya N, Kenmochi K, Hirohata R (August 1954). "Specificity of rabbit kidney demethylase". The Journal of Biological Chemistry. 209 (2): 485–92. PMID 13192101.


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