Multilocular_cystic_nephroma

Cystic nephroma

Cystic nephroma

Medical condition

A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST) and renal epithelial stromal tumour (REST),[1] is a type of rare benign kidney tumour.

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Symptoms

Cystic nephromas are often asymptomatic. They are typically discovered on medical imaging incidentally (i.e. an incidentaloma).

Diagnosis

Cystic nephromas are diagnosed by biopsy or excision. It is important to correctly diagnose them as, radiologically, they may mimic the appearance of a renal cell carcinoma that is cystic.[2]

Pathologic diagnosis

High magnification micrograph of a cystic nephroma showing the characteristic simple epithelium with hobnail morphology, and the ovarian-like stroma. H&E stain.

The characteristics of cystic nephromas are:

  • Cysts lined by a simple epithelium with a hobnail morphology, i.e. the nuclei of the cyst lining epithelium bulges into the lumen of the cysts,
  • Ovarian-like stroma that has a:
    • Spindle cell morphology, and has a
    • Basophilic cytoplasm.

Cystic nephromas have an immunostaining pattern like ovarian stroma; they are positive for:

Differential diagnosis

Histopathologic types of kidney tumor, with relative incidences and prognoses. Cystic nephroma is seen at bottom right in pie chart.

Additional images

References

  1. [1]
    Turbiner J, Amin MB, Humphrey PA, Srigley JR, De Leval L, Radhakrishnan A, Oliva E (April 2007). "Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term". The American Journal of Surgical Pathology. 31 (4): 489–500. doi:10.1097/PAS.0b013e31802bdd56. PMID 17414095.
  2. [2]
    Small JE, Jinnteh T, Hong X, Tuncali K, Seltzer SE, Ros PR (11 August 2003). "Cystic Nephroma". BrighamRAD Teaching Case Database. Archived from the original on 2004-10-24.
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This article uses material from the Wikipedia article Multilocular_cystic_nephroma, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.