Molybdopterin_molybdotransferase

Molybdopterin molybdotransferase

Molybdopterin molybdotransferase

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Molybdopterin molybdotransferase (EC 2.10.1.1, MoeA, Cnx1) is an enzyme with systematic name adenylyl-molybdopterin:molybdate molybdate transferase (AMP-forming).[1][2][3] This enzyme catalyses the following chemical reaction

adenylyl-molybdopterin + molybdate molybdenum cofactor + AMP
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Catalyses the insertion of molybdenum into the ene-dithiol group of molybdopterin.

References

  1. [1]
    Nichols JD, Rajagopalan KV (March 2005). "In vitro molybdenum ligation to molybdopterin using purified components". The Journal of Biological Chemistry. 280 (9): 7817–22. doi:10.1074/jbc.M413783200. PMID 15632135.
  2. [2]
    Nichols JD, Xiang S, Schindelin H, Rajagopalan KV (January 2007). "Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft". Biochemistry. 46 (1): 78–86. doi:10.1021/bi061551q. PMC 1868504. PMID 17198377.
  3. [3]
    Llamas A, Otte T, Multhaup G, Mendel RR, Schwarz G (July 2006). "The Mechanism of nucleotide-assisted molybdenum insertion into molybdopterin. A novel route toward metal cofactor assembly". The Journal of Biological Chemistry. 281 (27): 18343–50. doi:10.1074/jbc.M601415200. PMID 16636046.
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