Mark Twain (1835–1910) was an American writer.

Mark Twain may also refer to:

• Mark Twain (crater), a crater on Mercury
• 2362 Mark Twain, a main-belt asteroid
• Mark Twain, St. Louis, a neighborhood of St. Louis, Missouri, U.S.

• Mark Twain (film), a 2001 biographical documentary by Ken Burns
• Mark Twain, a Disney riverboat attraction at multiple theme parks
• Mark Twain: The Musical (1987), a stage musical biography by Jane Iredale and William P. Perry
• Mark Twain: Words & Music (2001), a music and spoken-word album

• The "Mark Twain", a prototype of the Apple IIGS
• "Mark twain", a nautical term related to the practice of depth sounding

• All pages with titles beginning with Mark Twain

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