2003–2010: Early works

Prebble's first full-length play The Sugar Syndrome was performed at the Royal Court in 2003^[11] and won her the George Devine Award, followed by the TMA Award for Best New Play in October 2004. Matt Wolf of Variety compared the play to Paula Vogel's How I Learned to Drive and added "And yet, even as you’re anticipating [the play's] every gear change...Prebble lifts yet another lid on the varieties of bruises, physical and emotional, that link her four characters. And Prebble chronicles with great skill the way in which parents and children often have the goods on each other, in this case the revelation of Jan’s husband’s adultery — which turns out not to be any revelation at all."^[12]

Her next theatre project ENRON, was based on the financial scandal and collapse of the American energy corporation of the same name. It was produced by theatre company Headlong at the Chichester Festival Theatre in 2009, under the direction of Rupert Goold. The production transferred first to the Royal Court and subsequently to the Noël Coward Theatre. The play earned Prebble an Olivier Award nomination for Best New Play. The production's Broadway transfer opened at the Broadhurst Theatre in April 2010 but failed to match the critical acclaim it received in the UK and closed the following month.^[13][14] The Associated Press wrote of the production, "Playwright Prebble and director Rupert Goold attempt to walk a fine line in the production, which is alternately naturalistic and highly stylized in its depiction of the rise and fall of the mammoth energy company that engaged in accounting fraud on an unprecedented level."^[15]

2012–present: Breakthrough and acclaim

The Effect, a study of love and neuroscience, premiered at the National Theatre in 2012, won the 2012 Critics' Circle Award for Best Play.^[16] The Effect premiered in the US Off-Broadway at the Barrow Street Theatre on 2 March 2016, directed by David Cromer, and featuring Kati Brazda, Susannah Flood, Carter Hudson and Steve Key.^[17] In 2019, it was listed in The Independent as one of the 40 most "continually rewarding" plays.^[18] In April 2017 it was announced that Prebble was working on a new play, based on Bizet's Carmen^[19], from the new Bridge Theatre in London.^[20]

In October 2018, London's Old Vic announced Prebble's A Very Expensive Poison, a stage adaptation of Luke Harding's non-fiction book of the same name. The play is about the assassination of Alexander Litvinenko by means of the invisible radioactive isotope polonium-210.^[21] The play opened at the Old Vic on 5 September 2019, directed by John Crowley.^[22] A Very Expensive Poison was nominated at the 2020 Laurence Olivier Awards for Best New Play ^[23] and won the Critics' Circle Theatre Award for Best New Play ^[24] and Best New Production of a Play at the Broadway World Awards. Prebble was also awarded the 2020 Susan Smith Blackburn Prize.^[25]

Her play The Effect had a revival in 2023 at the Royal National Theatre's Lyttelton Theatre in the West End before transferring to The Shed in New York City in 2024. The production was directed by Jamie Lloyd and stars Taylor Russell and Paapa Essiedu. Kate Wyver praised the production describing at "intense and intoxicating" adding, "[the play] remains an intellectually and physically intense experience, with subtle edits that sharpen and freshen the text for a stellar new cast".^[26]

2007–2017: Secret Diary of a Call Girl

Prebble wrote her first television series, the ITV2 drama-comedy series Secret Diary of a Call Girl based on the novel, The Intimate Adventures of a London Call Girl by Brooke Magnanti. Set in modern day London, the show revolves around a young woman, Hannah Baxter, played by Billie Piper who lives a secret life as a call girl. The series received positive reviews with Nancy Franklin of The New Yorker comparing the series favorably to Sex and the City writing, "The show also uses London in somewhat the same way “Sex and the City” used New York—we see a lot of bright lights, fancy restaurants, and expensive apartments—though there is a sadder, more wistful quality to the photography here".^[27] Prebble wrote for the first two of the show's four seasons, the last of which concluded in March 2011.

Prebble has also appeared as a guest on Frankie Boyle's New World Order and Have I Got News for You. Prebble contributes to major publications as a journalist and wrote a weekly Tech column for The Observer newspaper.^[28] She was the Head Scene Writer for Bungie's first person shooter video game, Destiny, which was released in September 2014. Prebble was hired in 2016 to write and executive produced an pilot for Sarah Silverman for HBO.^[29]

2018–2023: I Hate Suzie and Succession

From 2018 to 2023, Lucy served as a co-executive producer and writer on the acclaimed HBO drama Succession starring Brian Cox, Jeremy Strong, Sarah Snook, Kieran Culkin, and Matthew Macfadyen. The show revolved around the fictional Roy family, loosely based on the Murdoch family, each struggling to take power of the Family owned media company. The series received numerous accolades including several Golden Globe Awards and Primetime Emmy Awards. As a producer she won the Primetime Emmy Award for Outstanding Drama Series in 2020, 2022, and 2023. Prebble also won the Writers Guild of America Award for Television: Dramatic Series twice in 2019 and 2021.^[30] Prebble wrote two episodes of the series herself, the first one being "Austerlitz" (2018) from season 1. Scott Tobias of Vulture praised the episode writing, "it’s such a great opportunity to get to know the significant others in the Roys’ lives and see how they interact with their mates — and, hilariously, with each other".^[31] She wrote her second episode "Honeymoon States" (2023) from season 4. Alan Sepinwall of Rolling Stone praised the episode for its examination of the characters' greed in the wake of tragedy, and called the episode overall "sharp and funny"^[32] Noel Murray of The New York Times hailed the episode "one of the funniest of the series, filled with quotable lines and sick burns".^[33]

In 2020 Prebble reunited with Piper for a further television project, the comedy-drama series I Hate Suzie for Sky Atlantic.^[34] The series followed Piper as a former teenage pop star and television actress. The series had a second season in 2022 entitled, I Hate Suzie Too. The series received critical acclaim ending up on several best of lists. Lucy Mangan of The Guardian praised the collaboration between Prebble and Piper, calling the show a "wild ride that feels like an absolute gift."^[35] The series received four British Academy Television Award nominations as well as a win for Prebble for the Royal Television Society Programme Award for Best Writing in a Drama Series in 2023.^[36]