Lorenz, Lord of Werle-Güstrow (between 1338 and 1340 – between 24 February 1393 and 6 May 1394) was Lord of Werle-Güstrow from 1360 to 1393 (or 1394). He was the eldest son of Nicholas III, Lord of Werle-Güstrow and Agnes of Mecklenburg.

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After his father's death in 1360 or 1361, he initially ruled Werle-Gustrow alone. After 21 September 1365, he ruled jointly with his brother John V of Werle, as can be inferred from a deed they signed jointly on that date.^{[citation needed]}

John died young, before 9 September 1378. From that date onwards, documents were again signed by Lorenz alone. Lorenz last signed a deed on 24 February 1393.

He was married to Matilda (died before 17 December 1402), the daughter of Nicholas IV, Lord of Werle-Goldberg. They had the following children:

• Balthasar, lord of Werle-Güstrow,
• John VII, co-lord of Werle-Güstrow,
• William, Lord of Werle-Güstrow.

• Biographical data about Lorenz on emecklenburg.de
• Genealogical table of the House of Mecklenburg

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