A deadly tornado outbreak affected much of the central and Southern United States from April 29 – May 1, 1909. Affecting particularly the Mississippi and Tennessee Valleys, it killed over 180 people, more than 90 of them in the U.S. state of Tennessee alone. The deadliest and longest-tracked tornado of the outbreak was a violent F4 tornado family that tracked across portions of northern Mississippi and western Tennessee on April 29, claiming at least 29 lives. Another deadly F4 tornado struck portions of southern Tennessee early the next day, killing 31. Other F4s in southern Missouri and southern Illinois on April 29 killed a combined 16 people. Deadly F3s in Georgia and Tennessee from April 30–May 1 killed a total of at least 53 people as well.^{[nb 1][nb 2][nb 3]}

During the late afternoon and the overnight hours of April 29, 1909, numerous strong to violent tornadoes affected the areas of northern Alabama, eastern Arkansas, southern Illinois, northern Mississippi, southeastern Missouri, and western Tennessee (the NWS Memphis, Tennessee, coverage area). In that general area, at least 72 were killed by tornadoes.

The deadliest tornado touched down just south of the Tennessee-Mississippi state line in Desoto County and tracked east-northeast for about 145 miles (233 km) across Shelby, Fayette, Hardeman, Chester, Henderson and Decatur Counties. While it was estimated to be an F4, some reports indicate that there was more than one tornado. Among the towns affected were Horn Lake, Mississippi, where about half of the fatalities were recorded, and Whitehaven, Tennessee, where the tornado damaged 30 homes. The parent supercell continued on to produce additional tornadoes in Scott County.

North of Memphis, Tennessee, two F3 tornadoes killed a total of 22 from Crittenden County, Arkansas, to Carroll County, Tennessee. Homes were destroyed in Marion, Arkansas, resulting in five deaths in Arkansas. In Tennessee, the town of Locke was mostly destroyed by the first F3 tornado. The second F3 tornado flattened structures near Covington and Medina. Several of the injured people who later died were plantation workers. A family of tornadoes also affected Hickman and Williamson Counties southwest of Nashville and later moved into the city of Cookeville and Putnam County. Three other tornadoes killed four people in the Memphis coverage area, including in St. Francis and Lee Counties in Arkansas and Haywood County in Tennessee.

Other F4 tornadoes were reported in Missouri near Golden, in Illinois near Texas City, and in south-central Tennessee near Bee Spring, just north of the Alabama state line. 11 deaths were recorded in the Missouri storm, five near Texas City and 31 just north of the Alabama–Tennessee state line. The Bee Spring tornado affected parts of Lincoln and Giles Counties in Tennessee. Hardest-hit areas were in and around Pulaski, Bryson and Fayetteville. Another strong tornado struck Franklin County near Decherd.^[10]

• A tornado may have unroofed barns and homes at Monterey, Putnam County, Tennessee.^[11]

Prior to 2017, the outbreak, with 60 confirmed deaths, was the deadliest known tornado outbreak to affect Tennessee until March 21, 1952, when 64 people died statewide. However, reanalysis subsequently confirmed more than 90 fatalities in the state, once again making this outbreak the deadliest—even the April 3–4, 1974, Super Outbreak and the February 5–6, 2008, Super Tuesday outbreak produced just 45 and 31 deaths each in the state, respectively.^[11][17][21]

• List of North American tornadoes and tornado outbreaks