Kynurenate-7,8-dihydrodiol_dehydrogenase

Kynurenate-7,8-dihydrodiol dehydrogenase

Kynurenate-7,8-dihydrodiol dehydrogenase

Class of enzymes

In enzymology, a kynurenate-7,8-dihydrodiol dehydrogenase (EC 1.3.1.18) is an enzyme that catalyzes the chemical reaction

7,8-dihydro-7,8-dihydroxykynurenate + NAD+ 7,8-dihydroxykynurenate + NADH + H+
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Thus, the two substrates of this enzyme are 7,8-dihydro-7,8-dihydroxykynurenate and NAD+, whereas its 3 products are 7,8-dihydroxykynurenate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase. Other names in common use include 7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase, and 7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase. This enzyme participates in tryptophan metabolism.

References

    • Taniuchi H, Hayaishi O (January 1963). "Studies on the metabolism of kynurenic acid. III. Enzymatic formation of 7,8-dihydroxykynurenic acid from kynurenic acid". The Journal of Biological Chemistry. 238: 283–93. PMID 13984873.


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