KSC may refer to:

• Kalinga language (ISO 639 language code ksc)
• Karlsruher SC, a German association football club, based in Karlsruhe, Baden-Württemberg
• Keene State College, New Hampshire, US
• Kelsey-Seybold Clinic, Houston, US, NASA-affiliated
• Kennedy Space Center, Cape Canaveral, Florida, US
• Kenya Social Congress
• Kilogram-force per square centimetre
• Knights of Saint Columba, a UK Catholic lay society
• Knights of the Southern Cross, an Australian Catholic lay society
• Košice International Airport (IATA airport code KSC), Košice, Slovakia
• Kurtis Sport Car, US
• Communist Party of Czechoslovakia (Czech and Slovak: Komunistická strana Československa, KSČ), 1921-1992

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