José Guadalupe Rubio Talamantes (born 14 March 1966, in Gómez Palacio, Durango), known as Lupe Rubio, is a Mexican football manager and former player.

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Playing for Santos Laguna, Rubio partnered Pedro Muñoz de la Torre in the center of the club's defense for several seasons during the 1990s.^[1] Rubio was a key figure in defense as Santos reached the 1993–94 final and won the 1996 Invierno championship (the club's first title). In total, he scored eleven goals in 181 Primera División appearances for Santos.^[2]

After he retired from playing, Rubio was just the seventh Santos player voted as Guerrero de Honor by the readers of El Siglo de Torreón.^[3]