Joseph DeSa (July 27, 1959 – December 20, 1986) was a Major League Baseball first baseman.

Drafted by the St. Louis Cardinals in the 3rd round of the 1977 MLB amateur draft, DeSa made his Major League Baseball debut with the St. Louis Cardinals on September 6, 1980, and appeared in his final game on October 3, 1985, for the Chicago White Sox.

DeSa died in an automobile accident in the early morning hours of December 20, 1986 in Cayey, Puerto Rico. At the time of his death, he was playing in the Puerto Rico Professional Baseball League for the Ponce Lions.

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