Jean-Luc may refer to:

• Jean-Luc Bennahmias (born 1954), a French politician and Member of the European Parliament
• Jean-Luc Bourgeaux (born 1963), a French politician
• Jean-Luc Dehaene (1940–2014), a Flemish politician
• Jean-Luc Laurent (born 1957), a French politician
• Jean-Luc Mandaba (1943–2000), a former Prime Minister of the Central African Republic
• Jean-Luc Mélenchon (born 1951), a French politician
• Jean-Luc Pépin (1924–1995), a Canadian academic, politician, and Cabinet member
• Jean-Luc Poudroux (born 1950), a French politician

• Jean-Luc De Meyer (born 1957), a Belgian vocalist and lyricist best known as the lead vocalist of Front 242
• Jean-Luc Ponty (born 1942), a French virtuoso violinist and jazz composer
• Jean-Luc Picard, a fictional starship captain in the Star Trek universe
• Jean-Luc Bilodeau (born 1990), an actor, played Josh Trager on the television show Kyle XY and Ben Wheeler on Baby Daddy
• Jean-Luc, a character in the Bluey episode Camping

• Jean-Luc Cairon (1962–2022), French gymnast and coach
• Jean-Luc Godard (1930–2022), a Franco-Swiss filmmaker
• Jean-Luc Grand-Pierre (born 1977), a Canadian professional ice hockey defenceman
• Jean-Luc Lagardère (1928–2003), a major French businessman
• Jean-Luc Margot (born 1969), a Belgian astronomer and Professor at UCLA
• Jean-Luc Marion (born 1946), a French philosopher
• Jean-Luc Nancy (1940–2021), a French philosopher
• Jean-Luc du Plessis (born 1994), a South African Rugby Union player

• English : John Luke
• Italian : Gianluca
• French : Jean-Luc
• Spanish : Juan Lucas
• Portuguese : João Lucas

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