Isaacson is a surname meaning "son of Isaac", the Biblical figure. Notable people with the surname include:

• Doug Isaacson (born 1957), American politician
• Jacob Isaacson (1911–1980), American composer and musician
• James Isaacson (born 1980), English rugby union football player
• Megan Isaacson, American gospel singer
• Peter Isaacson (1920–2017), English-born Australian newspaper publisher and military pilot
• Rich Isaacson (born 1964), American music entrepreneur
• Richard A. Isaacson, American physicist and promoter of LIGO
• Thorpe B. Isaacson (1898–1970), American leader in The Church of Jesus Christ of Latter-day Saints
• Walter Isaacson (born 1952), American author, columnist and CEO

This page lists people with the surname Isaacson.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.