Interstate 105 may refer to either any of three unconnected Interstate Highways in the United States, each of which is or was related to Interstate 5:

• Interstate 105 (California), a spur of Interstate 5 in Los Angeles County, California
• Interstate 105 (California 1964–1968), a former part of U.S. Route 101 in downtown Los Angeles, California
• Interstate 105 (Oregon), a spur of Interstate 5 in Eugene, Oregon

This disambiguation page lists articles about roads and streets with the same name.
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