IL-1R

Interleukin-1 receptor

Interleukin-1 receptor

Cytokine receptor which binds interleukin 1

See also: Interleukin-1 receptor family

Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]

Quick Facts Identifiers, Symbol ...
Quick Facts Identifiers, Symbol ...
Quick Facts Identifiers, Symbol ...

The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]

References

  1. [1]
    Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway". J. Leukoc. Biol. 56 (5): 542–7. doi:10.1002/jlb.56.5.542. PMID 7964161. S2CID 43095473. Archived from the original (abstract page) on 2005-05-07. Retrieved 2008-02-28.
  2. [2]
    Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC 295645. PMID 1834696.
  3. [3]
    Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.


Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article IL-1R, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.