Hydrazine_(antidepressant)

Hydrazine (antidepressant)

Hydrazine (antidepressant)

Group of antidepressants

This article is about a series of antidepressants. For the toxic, unstable compound with the chemical formula N2H4, see hydrazine.

The hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (MAOIs) which were discovered and initially marketed in the 1950s and 1960s. Most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use.

Iproniazid, the first hydrazine MAOI to be discovered.

Tranylcypromine, a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing hepatotoxicity.

List of hydrazine antidepressants

Marketed

Legend: ‡ = Withdrawn from the market; † = Partially discontinued; Bolded names indicate major drugs.

Never marketed

Parkinson's

Tranquillosedative

  • Centazolone

References

    • López-Muñoz F, Alamo C (2009). "Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today". Current Pharmaceutical Design. 15 (14): 1563–86. doi:10.2174/138161209788168001. PMID 19442174. Archived from the original on 2013-04-14.
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