In Season 6, she is courted by a faerie/vampire hybrid named Ben Flynn, later revealed to be Warlow. He attempts to turn her into his faerie/vampire bride, though she refuses and is saved by Bill. She ends the season in a relationship with Alcide. In Season 7, she slowly rekindles her relationship with Bill and goes back to him after Alcide is killed. When he is infected with Hep V and chooses to die, she is devastated. But when he asks her to end his life and give up her faerie powers, she finally accepts her faerie powers as a gift and stakes him instead. Five years later, Sookie is seen happy, pregnant, and in a relationship with an unknown man, hosting all of her human and non-human friends for a dinner party at her house.

In early episodes, it is revealed that Bill had a human wife and two children (Tom and Sarah) before he became a vampire. A short time after being turned, Bill returns to his family in his desperation to see them one last time. He discovers that his son has recently died of an illness (pox). Upon seeing his tears of blood at the death of his son, his wife becomes hysterical, at which point Lorena, Bill's maker, steps in and glamors her before removing Bill from his family forever. The fates of Bill's wife and young daughter, who was not present during his return home, are unclear, although Adele Stackhouse refers to the recently deceased previous owner of Bill's family home as the last Compton in Bon Temps. In episode 4 of the fourth season, Bill becomes involved in a sexual relationship with Portia Bellefleur (sister of Sheriff Bellefleur) until, upon meeting her grandmother, he realizes she is a descendant of his daughter Sarah.

In the second season, Jason briefly becomes an active member of the Fellowship, but later leaves it. In the third season, he develops a relationship with a supernatural creature, Crystal Norris, and thinks of joining the police. Crystal is forced to leave town with her fiancé but Jason pledges to find her. Like his sister, Jason is also part faerie though he does not appear to have inherited any of the special abilities that Sookie possesses. However, some speculate that his potential faerie "ability" is the sexual magnetism that many faeries possess. In the fourth season, he is a deputy on the Bon Temps police force and caretaker of the were-panthers of Hotshot. He is kidnapped by Felton and Crystal who are now V-addicts and raped by all the women of the were-panther community after it is believed he is the "ghost daddy" meant to revive the dwindling numbers of the genetically weakened inbred pack. He manages to escape with Hot Shot and Crystal and kill Felton in the process, however, as a result of the excessive, untreated bites from attempting to be turned were-panther by the others, he is left on the side of the road badly wounded. He is found by Jessica, who tells him to "drink" and he is healed by her blood. When the witches cast a spell to bring the vampires out into the daylight, Jessica breaks free of her silver bonds and almost burns herself trying to walk out into the sunlight. Jason comes at the last second and takes her back into the house, closing the door and saving her life. Jason starts having intermittent sexual fantasies about Jessica—some involving Hoyt. Jessica and Jason finally do have sex after she breaks up with Hoyt. In the culmination of season 4, when The Moon Goddess Emporium is being held captive by Marnie, Jason tries to save Sookie, Tara, and everyone else inside. When Pam angrily fires a bazooka at the place, and it blows up at the protective barrier Marnie has placed around the emporium, all vampires present (Eric, Bill, Pam, and Jessica) heal quickly, but Jason is left severely burned and blind. Jessica once again offers her blood and saves his life. He admits his feelings to Jessica, and she also admits her own. They agree to have a relationship, but only as friends with benefits. Jessica states that she just got out of her first and only serious relationship, and doesn't want to be tied down to anyone. With the season 5 premiere, Jason is greeted by Rev. Steve Newlin, who admits to Jason he's always had feelings for him. When Jason kindly rejects him, Newlin loses it and tries to bite Jason. Jessica rushes back and says "Jason is mine", then threatens the Rev. with either leaving Jason alone - or the true death. Jason tries to cope with his feelings for Jessica in their casual relationship and turns down advances from other girls despite his open relationship status. After running into his high school teacher, who is revealed to have slept with an underage Jason, he struggles with his inner demons; saying that there is a big hole in him, with something just missing - and he's been trying to fill it with sex, which so far has worked - but now it is not. And he doesn't know how to be friends with a girl. Jessica, who is present for this speech - says that he is already friends with a girl and that she is there to talk and listen to him. Jason later goes to a secret club with Sheriff Andy and Judge Clements, which is revealed to be a fairy safehouse. When the girl he is with reads his mind, he realizes the supernatural aura of the place and then sees his cousin Hadley. She explains that he and Sookie must join her and the other faeries or the vampires will kill them, as they did their parents. Jason, believing his parents died in a flood, tries to get more information from Hadley but gets kicked out of the club with Sheriff Andy and presumably attacked by 2 male faeries.

Tara is later abducted by a delusional vampire who believes she loves him. He holds her captive for many days, even taking her to the mansion of Russell Edgington, for whom he works, where he plans to turn her into a vampire. She eventually escapes the vampire by tricking him into letting her drink his blood so she would have the power to smash his skull with one of the weapons that adorned the wall of their room. However this does not kill him and he comes after her, eventually being killed by Jason at Merlotte's. Tara ends up traumatized by her experience and after discovering that Jason had been the one who killed Eggs, cuts off her hair and leaves Bon Temps. In season 4, Tara has moved to New Orleans and working as a cage fighter, and is in a relationship with another fighter, Naomi. In the season 4 finale, Tara is shot in the head by Debbie. Sookie picks her up from a pool of her own blood, cradling her and screaming for help. Pam enters Sookie's house looking for Eric and sees the dead bodies of Debbie and Tara on the floor. At Sookie and Lafayette's behest, Pam turns Tara into a vampire. Because half of her brain was previously missing before the healing process brought on by Pam's turning of her, not only is Tara now a vampire, but there is now a severe personality change. Tara and Pam become very close over the course of season 5 and Tara begins to deeply care for her new maker. At the end of the season, Tara rescued Pam from the Vampire Authority and the two shared a long, heartfelt kiss. Tara was killed at the beginning of season 7 by one of the wild Hep V vamps while fighting to save her mother.

Many of the others in Bon Temps are quite accepting of Lafayette's sexuality, and while he is quite open about it, almost to the point of flaunting it, he doesn't do so to the point of making anyone uncomfortable. On the rare occasion someone, usually a traveller passing through, makes a homophobic remark, he is quick to defend himself and is very capable of doing so, both verbally and physically, with many in the community backing him up.

Lafayette is killed at the beginning of the second novel in the series. In True Blood, he is saved due to the popularity of his character and to help expand Tara Thornton's role in the series.

In casting, Alan Ball had concerns that the character's sexuality would be a dominating trait, "because you don't want to bring in someone who's going to play that in a phony way".^[2] Nelsan Ellis says that it took him a few episodes to find the character.^[3] Ellis says that he based many of Lafayette's mannerisms on his mother and his sister,^[2] and that the costuming also helps him get into character.

I have more makeup on than any of the females in the cast. Once they get me with the fake eyelashes and the eye makeup, I listen to some Rihanna and I'm there.

— Nelsan Ellis, The Philadelphia Inquirer

Alcide informs the pack that it was he who killed their packmaster, Marcus, so they would release Sam whom they thought had killed Marcus, Alcide covers up the fact that Sookie had killed Debbie had they spend the night together. Alcide finds out their new packmaster is working for Edgingtion and is giving the pack V; Alcide does everything in his power to stop it. Recently, Alcide accepted the role of packmaster, a position he never aspired to have. While being packmaster, Alcide was more aggressive and became more of a leader than a lone wolf. He did enjoy the benefits of packmaster, such as control over the pack and thavingany female pack member he wanted. However, even though Alcide inherited the flesh of JD, most of his pack, like Rikki, ignores his commands. Alcide's pack's aggressive behaviour, and murder of the students who tried to persuade them to reveal their existence, publicly frustrates him. He despises violence and unsuccessfully tries to cover up Nicole's escape. When Rikki confronts him with Nicole and Nicole's mom's capture, proving the packmaster lied to his own pack, Rikki charges Alcide with the assistance of two female werewolves but Alcide finishes them off, though he restrains from killing them. He then walks away and turns his back on werewolf society, befriending Sam Merlotte once again. Alcide turns up at Terry's funeral to support Sookie and the two start a relationship. In season 7 Alcide is killed by the town's hate group against supernaturals.

In season 7, after the death of Tara, Willa becomes slightly depressed because, with the disappearance of Pam and Eric, she is all alone. Eric returns to Bon Temp and tells Pam that Willa is still part of their family and he must say goodbye to her in person before he dies. Eric summons Willa, and though Eric appears genuinely happy to see his young progeny, she angrily yells at him for abandoning her so soon after she was made. Along with the other healthy vampires, she fights the Hep V Vamps. Willa is later released from Eric. Eric apologizes and tells her that he is proud to have her in the family. At the end of the series, Willa, now working for Arlene, is last seen with Sookie, Sam, Jason, Jessica, and Arlene at Sookie's house for a Thanksgiving celebration.

In season 4, it is revealed that she is one of Marnie's students and a member of her coven. After the incident with Eric, she leaves the coven, while she still is a waitress at Merlotte's, Sookie reads her mind and finds out that she has abandoned Marnie's witch coven for her and her sons' safety. Tara asks her to rejoin the coven and take revenge on the vampires who attacked them, Marnie betrays the coven for her own quest for power. She then begins to date Andy Bellefleur at the end of Season 4. In season 7, Holly is one of several characters captured by Hep-V vampires. She is rescued by Sookie and Bill when the vamps take her on a "field trip" as a food source. Sookie then later uses her powers to jog Holly's memories in order to find out the other prisoners are being held in the abandoned Fangtasia. In episode 5, Andy proposed to Holly, and she accepted.

Rene appears to Arlene in the season 4 finale and warns her about Terry. He tells her he's met the ghosts of Terry's past and she must run.

He abducts Bill in season three in hopes of gathering intel on the queen of Louisiana, who he hopes to marry in order to merge their respective kingdoms. After discovering that Sookie has unusual abilities, Russell takes an interest in her. When Bill is no longer of use to him, he orders Bill's execution, but Sookie thwarts his plans. After Eric kills Russell's consort Talbot in retaliation for Russell murdering Eric's human family centuries ago, Russell becomes hysterical and kills an anchorman on live television to address a statement to the world, in which he announces his view that vampires and humans aren't equals and vampires will rule over them. This has widespread fallout as shown in season 4 with the vampires focusing hard on improving their image. Eric, Sookie and Bill manage to dispose of Russell at the end of the third season by tricking him and burying him underneath concrete.

In the season 4 finale it is implied that Russell has escaped the concrete, when Alcide finds a mysterious hole in a parking garage floor with silver chains discarded near it.

In season 5 it is revealed that he was released from concrete by Salome, to serve her agenda. He managed to kill Roman, the Magister of the Authority and escape once more. He goes against the Authority again when his proposition to drain all faeries in order to gain the ability to walk in sunlight is rejected. He was staked by Eric Northman in the finale of Season 5.

The two do not meet again for more than 70 years when, in season 2, she is summoned to the vampire hotel in Texas by Eric who, in his desperation to find Godric, schemes with her to hold Bill captive while Sookie infiltrates the Fellowship of the Sun so that he cannot interfere. Lorena is coerced into Eric's plan. Her love and longing for Bill has intensified over the years and as she holds him captive the two share memories of their twisted past together. Bill eventually escapes after hitting her over the head with a plasma television. Lorena makes an appearance at the party after Godric is freed from the Fellowship of the Sun and challenges Sookie who aggressively defends her relationship with Bill and warns Lorena to stay away from him. When she tries to attack Sookie, she is stopped by Godric who again comments on her old age and how she has not bettered herself over so much time. He then orders her to leave his domain, which she begrudgingly does, but not before an emotional departing with Bill outside.

Lorena returns in season 3 when Bill is captured by Russell Edgington. At the time, she appears to have been living as a guest in Russell's mansion. Upon seeing Lorena, Bill becomes enraged and hurls a lamp at her, engulfing her in flames, but she survives. Russell leaves Bill to Lorena and though at first Bill resists her advances, the two end up having violent sex, and he twists her neck 180 degrees. After this he calls Sookie and ends their relationship though he does so only to protect Sookie and delude Lorena into believing he has returned to her. Eventually Bill's deception becomes apparent, and she resolves to kill him per instructions from Russell. She spends a lengthy and very emotional time torturing him in the servants' house on the mansion grounds before allowing werewolves to feed on his blood. When Sookie escapes from Russell and bursts into the room to save Bill, Lorena attacks her, but Sookie gets the upper hand and plunges a piece of wood into Lorena's chest, killing her.