Homospermidine_synthase

Homospermidine synthase

Homospermidine synthase

Enzyme

Homospermidine synthase (EC 2.5.1.44) is an enzyme with systematic name putrescine:putrescine 4-aminobutyltransferase (ammonia-forming).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

(1) 2 putrescine sym-homospermidine + NH3 + H+
(2) putrescine + spermidine sym-homospermidine + propane-1,3-diamine
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The reaction of this enzyme occurs in three steps.

References

  1. [1]
    Tait GH (February 1979). "The formation of homospermidine by an enzyme from Rhodopseudomonas viridis [proceedings]". Biochemical Society Transactions. 7 (1): 199–201. doi:10.1042/bst0070199. PMID 437275.
  2. [2]
    Böttcher F, Ober D, Hartmann T (1994). "Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation". Can. J. Chem. 72: 80–85. doi:10.1139/v94-013.
  3. [3]
    Yamamoto S, Nagata S, Kusaba K (July 1993). "Purification and characterization of homospermidine synthase in Acinetobacter tartarogenes ATCC 31105". Journal of Biochemistry. 114 (1): 45–9. doi:10.1093/oxfordjournals.jbchem.a124137. PMID 8407874.
  4. [4]
    Srivenugopal KS, Adiga PR (August 1980). "Enzymic synthesis of sym-homospermidine in Lathyrus sativus (grass pea) seedlings". The Biochemical Journal. 190 (2): 461–4. doi:10.1042/bj1900461. PMC 1162113. PMID 7470060.
  5. [5]
    Ober D, Tholl D, Martin W, Hartmann T (1996). "Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli". J. Gen. Appl. Microbiol. 42 (5): 411–419. doi:10.2323/jgam.42.411.
  6. [6]
    Ober D, Hartmann T (December 1999). "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14777–82. Bibcode:1999PNAS...9614777O. doi:10.1073/pnas.96.26.14777. PMC 24724. PMID 10611289.
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