Transport system |
Light subunit |
Heavy subunit |
Tissue distribution |
Substrates |
Affinity |
Sodium dependence |
Disease linkage |
L |
LAT1 (SLC7A5) |
4F2hc (SLC3A2) |
kidney, liver, intestine, brain, heart lung, blood–brain barrier |
large neutral amino acids, thyroid hormones |
micromolar |
no |
– |
L |
LAT2 (SLC7A8) |
4F2hc (SLC3A2) |
kidney, intestine, brain, liver, muscle, heart, lung |
smaller neutral amino acids |
millimolar |
no |
– |
y+L |
y+LAT1 (SLC7A7) |
4F2hc (SLC3A2) |
kidney, intestine, lung, erythrocytes, leukocytes |
large neutral amino acids, dibasic amino acid exchange |
micromolar |
yes |
Lysinuric protein intolerance |
y+L |
y+LAT2 (SLC7A6) |
4F2hc (SLC3A2) |
brain, intestine, heart, kidney, lung, liver |
neutral amino acids, dibasic amino acid exchange, glutamine/arginine exchange |
millimolar |
yes |
– |
xc− |
xCT (SLC7A11) |
4F2hc (SLC3A2) |
macrophages, liver, kidney, brain |
glutamine/cystine exchange |
|
no |
– |
asc |
ascAT1 (SLC7A10) |
4F2hc (SLC3A2) |
brain, lung, small intestine, kidney |
small neutral amino acids |
|
no |
– |
b0,+ |
b0,+AT1 (SLC7A9) |
rBAT (SLC3A1) |
kidney, intestine, brain |
neutral/dibasic amino acids |
|
no |
Cystinuria type I |