Guanase
Guanine deaminase
Mammalian protein found in Homo sapiens
Guanine deaminase also known as cypin, guanase, guanine aminase, GAH, and guanine aminohydrolase is an aminohydrolase enzyme which converts guanine to xanthine.[5][6][7] Cypin is a major cytosolic protein that interacts with PSD-95. It promotes localized microtubule assembly in neuronal dendrites.[8]
Quick Facts GDA, Available structures ...
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Aliases | GDA, guanine deaminase, CYPIN, GUANASE, NEDASIN, Guanine deaminase, GAH | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 139260; MGI: 95678; HomoloGene: 3171; GeneCards: GDA; OMA:GDA - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Hitchings GH, Falco EA (Oct 1944). "The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase". Proceedings of the National Academy of Sciences of the United States of America. 30 (10): 294–7. Bibcode:1944PNAS...30..294H. doi:10.1073/pnas.30.10.294. PMC 1078714. PMID 16578130.
- Kalckar HM (1947). "Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism". J. Biol. Chem. 167 (2): 461–75. doi:10.1016/S0021-9258(17)30999-7. PMID 20285041.
- Rabinowitz JC, Barker HA (Jan 1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations". The Journal of Biological Chemistry. 218 (1): 161–73. doi:10.1016/S0021-9258(18)65881-8. PMID 13278325.
- Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS (1999). "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting". Neuron. 24 (3): 659–72. doi:10.1016/S0896-6273(00)81120-4. PMID 10595517.
- Guanine+deaminase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q9Y2T3 (Human Guanine deaminase) at the PDBe-KB.