Glycine_dehydrogenase_(cyanide-forming)

Glycine dehydrogenase (cyanide-forming)

Glycine dehydrogenase (cyanide-forming)

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In enzymology, a glycine dehydrogenase (cyanide-forming) (EC 1.4.99.5) is an enzyme that catalyzes the chemical reaction

glycine + 2 A hydrogen cyanide + CO2 + 2 AH2
Quick Facts Identifiers, EC no. ...

Thus, the two substrates of this enzyme are glycine and A, whereas its 3 products are hydrogen cyanide, CO2, and AH2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with other acceptors. The systematic name of this enzyme class is glycine:acceptor oxidoreductase (hydrogen-cyanide-forming). Other names in common use include hydrogen cyanide synthase, and HCN synthase.

References

    • Wissing F (1975). "Cyanide production from glycine by a homogenate from a Pseudomonas species". J. Bacteriol. 121 (2): 695–9. PMC 245984. PMID 234422.
    • Castric PA (1977). "Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis". J. Bacteriol. 130 (2): 826–31. PMC 235287. PMID 233722.
    • Haas D; Blumer, C; Von Schroetter, C; Gaia, V; Défago, G; Keel, C; Haas, D (1998). "Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0". J. Bacteriol. 180 (12): 3187–96. PMC 107821. PMID 9620970.
    • Blumer C, Haas D (2000). "Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis". Arch. Microbiol. 173 (3): 170–7. doi:10.1007/s002039900127. PMID 10763748.


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