Giuliano di Lorenzo de' Medici KG (12 March 1479 – 17 March 1516) was an Italian nobleman, the third son of Lorenzo the Magnificent, and a ruler of Florence.

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Giuliano de' Medici
Portrait of Giuliano de' Medici, after Raphael.
Lord of Florence
Reign	9 March 1513 – 17 March 1516
Predecessor	Giovanni di Lorenzo de' Medici
Successor	Lorenzo ΙΙ de' Medici
Born	12 March 1479 Florence, Republic of Florence
Died	17 March 1516(1516-03-17) (aged 37) Florence, Republic of Florence
Noble family	Medici
Spouse(s)	Filiberta of Savoy
Issue	Ippolito de' Medici (illegitimate)
Father	Lorenzo I de' Medici
Mother	Clarice Orsini

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Born in Florence, he was raised with his brothers Piero and Giovanni di Lorenzo de' Medici, who became Pope Leo X; as well as his cousin Giulio de' Medici, who became Pope Clement VII.

His older brother Piero was briefly the ruler of Florence after Lorenzo's death, until the republican faction drove out the Medici in 1494. Giuliano moved therefore to Venice. The Medici family was restored to power after the Holy League drove the French forces that had supported the Florentine republicans from Italy. This effort was headed by Spain with the support of Pope Julius II. Giuliano reigned in Florence following his brother's election to the papacy in 1513, until he died in 1516.

He married Filiberta (1498–1524), daughter of Philip II, Duke of Savoy, on 22 February 1515 at the court of France,^[1] thanks to the intercession of his brother Giovanni, now pope as Leo X, in the same year that King Francis I of France (Filiberta's nephew) invested him with the title Duke of Nemours (which had recently reverted once again to the French crown) on the occasion. The French were apparently grooming him for the throne of Naples (in which the French maintained a historical interest), when Giuliano died prematurely. He was succeeded in Florence by his nephew Lorenzo II de' Medici.

Giuliano left a single illegitimate son, Ippolito de' Medici, who became a cardinal.

His portrait, painted in Rome by Raphael (a painter favored by Leo), shows Rome's Castel Sant'Angelo behind a curtain. (A studio version is at the Metropolitan Museum of Art.)

Giuliano's tomb in the Medici Chapel^[2] of the Church of San Lorenzo, Florence, is ornamented with the Night and Day of Michelangelo, along with a statue of Giuliano by Michelangelo. He shares an identical common name (Giuliano de' Medici) with his uncle Giuliano di Piero de' Medici, whose tomb is also in the Medici Chapel and who is famous for having been assassinated in the Pazzi Conspiracy.