2020: Three-year-old season

Gamine made her debut as a three-year-old on March 7 at Santa Anita Park in a Maiden race. She won this race by going straight to the front and winning by 6+1⁄4 lengths.

Her next race was an Allowance Optional Claiming on May 2 at Oaklawn Park. As in her last start, she went straight to the front. At the end of the race, she slowed down but won by a neck. Shortly after the race, Gamine tested positive for lidocaine. The Arkansas Derby (Div. 1) winner Charlatan also tested positive.

Bob Baffert said in a statement that he believes both horses were "unknowingly and innocently" exposed to lidocaine by one of his stable employees. The employee had broken his pelvis and was suffering from back pain in the days leading up to May 2. He applied a pain-relieving patch, which contained small amounts of lidocaine, according to Baffert's statement.

Gamine ran next in the Acorn Stakes on June 20 at Belmont Park. She ran fast fractions right from the start and opened up in the stretch to win by 18+3⁄4 lengths. She broke You's race record by 1.55 seconds and was 0.31 seconds slower than the track record. After the Acorn, Gamine became the favorite for the Kentucky Oaks and got 50 points for the 2020 Road to the Kentucky Oaks.

She was then taken to Saratoga for the Test Stakes on August 8. She won by 7 lengths and again set a stakes record.

On September 4, Gamine started at Churchill Downs in the Kentucky Oaks, where she met Alabama Stakes winner Swiss Skydiver, who was the 2nd favorite after Gamine. Again Gamine went to the front but slowed down in the stretch and was overtaken by long shot Shedaresthedevil and Swiss Skydiver. Gamine finished third. After the Kentucky Oaks, Gamine tested positive again, this time for betamethasone.

"The medication was administered to Gamine on August 17 by her veterinarian and on the veterinarian's recommendation. Importantly, the veterinarian followed established medical and regulatory guidelines in administering the medication, The withdrawal guidelines published by the Kentucky Horse Racing Commission recommend that the medication not be given within 14 days of a race. In this instance, as an additional layer of protection, Gamine's veterinarian last treated her with betamethasone 18 days before the Oaks."

Gamine was disqualified to last place.

Gamine's next start came in the Breeders' Cup Filly & Mare Sprint, which took place on November 7 at Keeneland. Her opponents included Serengeti Empress and Bell's the One. Serengeti Empress went to the front with Gamine stalking. They ran fractions of 21.77 and 44.27 through the half mile.

In the stretch, Gamine overtook Serengeti Empress to win by 6+1⁄4 lengths in a time of 1:20.20, which broke the stakes record and the track record.

Gamine was named American Champion Female Sprint Horse for 2020.

In the 2020 World's Best Racehorse Rankings, Gamine was rated 122, making her the equal twenty-first best racehorse in the world and the best three-year-old filly alongside Love and Swiss Skydiver.^[2]

2021: Four-year-old season

On April 4, Gamine made her first start at age 4. She ran in the Las Flores Stakes in Santa Anita Park in preparation for the Derby City Distaff Stakes at Churchill Downs. Gamine took the lead, running fractions of 22.74 and 45.77. With John R. Velazquez aboard, she won by 5 lengths in a time of 1:09.52.

After the race, her trainer Bob Baffert said she was one of the best one-turn mares he has ever trained.

On May 1, in the Derby City Distaff Stakes at Churchill Downs, she ran against Sconsin and Bell's the One. She got off to a slow start but soon took the lead and set fractions of 23.15 and 46.08. In the stretch, Sconsin made a run at Gamine, but she held on to win by 1+1⁄2 lengths. Her final time was 1:21:50 for 7 furlongs.

The next start was the Great Lady M. Stakes, in Los Alamitos, on July 5. Gamine took the lead from the start and set fractions of 21.61 and 44.32. She won by 10 lengths in a time of 1:14.98 for 6+1⁄2 furlongs.

After that, she was brought to Saratoga for the Ballerina Handicap against a strong field. Gamine got off to a good start and set fractions of 23.20, 45.68 and 1:09.20. In the end, she won by 1+3⁄4 lengths in a time of 1:21.39.

On November 6, Gamine was a hot 2/5 odds-on favorite in her attempt to repeat winning the Breeders' Cup Filly & Mare Sprint at Del Mar. In a five horse field Gamine started well leading through the first three furlongs but was collared on the turn and was soundly beaten into third place by Ce Ce.^[3]