GSTT1

GSTT1

GSTT1

Protein-coding gene in the species Homo sapiens

Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene.[2]

Quick Facts Available structures, PDB ...

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[3]


References

  1. [1]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. [2]
    Webb G, Vaska V, Coggan M, Board P (Jun 1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.
  3. [3]
    "Entrez Gene: GSTT1 glutathione S-transferase theta 1".
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