Frank Murphy (1890–1949) was a governor of Michigan and later justice of the United States Supreme Court.

Frank Murphy may also refer to:

• Frank Murphy (architect) (1916–1993), Irish architect
• Frank Murphy (radio personality) (fl. 1980s–present), American radio producer / deejay
• Frank Murphy, fictional character from the 1983 film Blue Thunder
• Frank Murphy, fictional character in the 2003 film Pullin' the Devil by the Tail
• Frank Murphy, fictional character in the American television series F Is for Family

• Frank Reid Murphy (1844–1892), Australian politician, member of the Queensland Legislative Assembly
• B. Frank Murphy (1867–1938), U.S. representative from Ohio
• Frank Murphy (Michigan legislator) (1878–?), American politician, Michigan state representative
• Frank Murphy (public servant) (1893–1949), Australian public servant
• Frank E. Murphy (1896–?), American politician, Michigan state representative
• Frank Murphy (lieutenant governor) (1897–1944), American politician, lieutenant governor of Michigan
• Frank Murphy Jr. (born 1934), American politician, California state assemblyman

• Frank Murphy (baseball) (1876–1912), American Major League Baseball player
• Frank Murphy (pole vaulter) (1889–1980), American pole vaulter
• Frank Murphy (footballer, born 1900) (1900–1953), Australian rules footballer for Carlton and Hawthorn
• Frank Murphy (Australian rules footballer) (1905–1995), Australian rules footballer for Collingwood
• Frank Murphy (footballer, born 1915) (1915–1984), Scottish footballer for Celtic
• Frank Murphy (sports administrator) (born 1944), Irish athletic administrator
• Frank Murphy (runner) (1947–2017), Irish middle-distance runner
• Frank Murphy (footballer, born 1959), Scottish footballer for Kettering and Nuneaton
• Frank Murphy (gridiron football) (born 1977), American NFL football player
• Frank Murphy (rugby union) (born 1981), Irish rugby union player

• Frank E. Murphy (farmer) (fl. early 1900s), American businessman in Wisconsin who developed Murphy Farms Number 1

• Francis Murphy (disambiguation)
• Franklin Murphy (disambiguation)

This disambiguation page lists articles about people with the same name.
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