Francis MacKenzie (born 1960) is former leader of the Nova Scotia Liberal Party.

Francis Mackenzie may also refer to:

• Francis Mackenzie, 1st Baron Seaforth (1754–1815), British politician and general
• Francis Wallace Mackenzie (1824–1892), member of parliament for Otago, New Zealand
• Francis Mackenzie (missionary) (1833–1895), Scottish member of the Plymouth Brethren
• Francis Mackenzie, 2nd Earl of Cromartie (1852–1893), British peer

• Frank Mackenzie Ross (1891–1971), Lieutenant Governor of British Columbia

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